Cytosolic Catechols Inhibit -Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates
نویسندگان
چکیده
منابع مشابه
Neurobiology of Disease Cytosolic Catechols Inhibit -Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates
Joseph R. Mazzulli,1 Amanda J. Mishizen,1,3 Benoit I. Giasson,2 David R. Lynch,1,3 Steven A. Thomas,2 Akira Nakashima,4 Toshiharu Nagatsu,5 Akira Ota,4 and Harry Ischiropoulos1,2,3 1The Joseph Stokes Jr. Research Institute and Departments of 2Pharmacology and 3Pediatrics, The Children’s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, Pennsylvania 19104, and Department...
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15 صفحه اولFormation of Toxic Oligomeric α-Synuclein Species in Living Cells
BACKGROUND Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders. Although fibrillar alpha-synuclein is a major component of Lewy bodies (LBs), recent data implicate prefibrillar, oligomeric intermediates as the toxic species. However, to date, oligomeric species have not...
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KEY POINTS The presynaptic protein α-synuclein forms aggregates during Parkinson's disease. Accumulating evidence suggests that the small soluble oligomers of α-synuclein are more toxic than the larger aggregates appearing later in the disease. The link between oligomer toxicity and structure still remains unclear. In the present study, we have produced two structurally-defined oligomers that h...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2006
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0896-06.2006